Sjögren's syndrome: autoimmune epithelitis
Identifieur interne : 002484 ( Main/Exploration ); précédent : 002483; suivant : 002485Sjögren's syndrome: autoimmune epithelitis
Auteurs : Menelaos N. Manoussakis [Grèce] ; Haralampos M. Moutsopoulos [Grèce]Source :
- Best Practice & Research Clinical Rheumatology [ 1521-6942 ] ; 2000.
English descriptors
- KwdEn :
- Teeft :
- Aberrant activation, Aberrant expression, American journal, Atrophic gastritis, Autoantibody, Autoimmune, Autoimmune diseases, Autoimmune disorder, Autoimmune epithelitis, Bacterial infection, Biopsy, British journal, Candidate autoantigen, Chronic disease, Chronic reactions, Clinical entities, Clinical features, Clinical pathology, Clinical presentation, Clinical spectrum, Connective tissue disease, Constitutional symptoms, Correct diagnosis, Crest variant, Dental disease, Diagnostic criteria, Diagnostic criterion, Disease activity, Disease complications, Disease course, Disease manifestations, Disease pathogenesis, Disorder, Dryness, Easy fatigue, Elderly individuals, Elderly subjects, Enlargement, Eosin stain, Epithelial, Epithelial apoptosis, Epithelial cells, European community, European criteria, Exocrine, Exocrine glands, Extraglandular, Extraglandular disease, Extraglandular manifestations, Focus score, Follicular bronchiolitis, General population, Gland, Gland biopsy, Gland enlargement, Glandular, Glandular epithelia, Glandular epithelial cells, Glandular tissues, Glomerulonephritis, Higher prevalence, Higher risk, Human virus, Immune, Immune system, Immunological aspects, Immunosuppressive agents, Internal medicine, Interstitial, Interstitial nephritis, Kassan, Lacrimal glands, Lesion, Local application, Lymphocytic, Lymphoma, Lymphoma development, Lymphomatous transformation, Malignant, Malignant lymphoma, Manifestation, Manoussakis, Membranoproliferative glomerulonephritis, Monoclonal, Monoclonal cryoglobulinaemia, Moutsopoulos, Moutsopoulos figure, Mucosal dryness, Nailfold capillaroscopy, Nephritis, Objective tests, Ocular components, Parotid, Parotid glands, Pathogenesis, Peripheral neuropathy, Pilocarpine hydrochloride, Positive response, Positive result, Practical algorithm, Primary biliary cirrhosis, Primary syndrome, Recurrent parotid gland enlargement, Renal, Rheumatic, Rheumatic disease, Rheumatic diseases, Rheumatoid arthritis, Rheumatology, Salivary, Salivary gland enlargement, Salivary gland epithelial cells, Salivary glands, Sarcoidosis, Secondary syndrome, Sequential application, Serological, Serological evaluation, Serum autoantibodies, Serum levels, Sicca, Sicca manifestations, Sicca syndrome, Symptomatic relief, Syndrome, Systemic, Systemic involvement, Systemic lupus erythematosus, Systemic manifestations, Systemic necrotizing vasculitis, Systemic sclerosis, Talal, Unpublished observations, Vaginal dryness, Variable severity, Vasculitis, Xerophthalmia, Xerostomia.
Abstract
Abstract: Sjögren's syndrome (SS) is a chronic autoimmune disorder of the exocrine glands of unknown aetiology, which is typically associated with focal lymphocytic infiltrates of glandular tissues and autoantibody responses against the Ro(SSA) and La(SSB) ribonucleoproteins. In almost one-third of patients disease involves various extraglandular sites, whereas approximately 5% of patients may also develop malignant B-cell lymphoma. In addition, features of SS are frequently encountered (5–20%) in patients with several other autoimmune rheumatic diseases, and in several respects these ‘secondary’ forms may be distinct from SS found alone (primary-SS), as well as from each other. The correct diagnosis and management of SS may require consideration from various specialists. Differential diagnosis includes adverse effects of drugs, sarcoidosis, lipoproteinaemias, age-related atrophy, chronic graft-versus-host disease, lymphomas, amyloidosis and infection by human immunodeficiency virus or hepatitis C virus. Based on the sequential application of the validated European classification criteria for SS, a practical algorithm for diagnosis is presented. Despite progress in the understanding of the broad clinicopathological spectrum of the entity, its treatment remains largely empirical and symptomatic. To date, the decision for systemic therapeutic intervention is primarily based on the severity of extraglandular manifestations.
Url:
DOI: 10.1053/berh.1999.0078
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001663
- to stream Istex, to step Curation: 001663
- to stream Istex, to step Checkpoint: 001301
- to stream Main, to step Merge: 002512
- to stream Main, to step Curation: 002484
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sjögren's syndrome: autoimmune epithelitis</title>
<author><name sortKey="Manoussakis, Menelaos N" sort="Manoussakis, Menelaos N" uniqKey="Manoussakis M" first="Menelaos N." last="Manoussakis">Menelaos N. Manoussakis</name>
</author>
<author><name sortKey="Moutsopoulos, Haralampos M" sort="Moutsopoulos, Haralampos M" uniqKey="Moutsopoulos H" first="Haralampos M." last="Moutsopoulos">Haralampos M. Moutsopoulos</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:F382C1419359434234091184862183D7082266B1</idno>
<date when="2000" year="2000">2000</date>
<idno type="doi">10.1053/berh.1999.0078</idno>
<idno type="url">https://api.istex.fr/ark:/67375/6H6-XZ98W64B-F/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001663</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001663</idno>
<idno type="wicri:Area/Istex/Curation">001663</idno>
<idno type="wicri:Area/Istex/Checkpoint">001301</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001301</idno>
<idno type="wicri:doubleKey">1521-6942:2000:Manoussakis M:sjogren:s:syndrome</idno>
<idno type="wicri:Area/Main/Merge">002512</idno>
<idno type="wicri:Area/Main/Curation">002484</idno>
<idno type="wicri:Area/Main/Exploration">002484</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Sjögren's syndrome: autoimmune epithelitis</title>
<author><name sortKey="Manoussakis, Menelaos N" sort="Manoussakis, Menelaos N" uniqKey="Manoussakis M" first="Menelaos N." last="Manoussakis">Menelaos N. Manoussakis</name>
<affiliation wicri:level="3"><country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Pathophysiology, School of Medicine, National University of Athens, 75 Mikras Asias str. 11527, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moutsopoulos, Haralampos M" sort="Moutsopoulos, Haralampos M" uniqKey="Moutsopoulos H" first="Haralampos M." last="Moutsopoulos">Haralampos M. Moutsopoulos</name>
<affiliation wicri:level="3"><country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Pathophysiology, School of Medicine, National University of Athens, 75 Mikras Asias str. 11527, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Best Practice & Research Clinical Rheumatology</title>
<title level="j" type="abbrev">YBERH</title>
<idno type="ISSN">1521-6942</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="2000">2000</date>
<biblScope unit="volume">14</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="73">73</biblScope>
<biblScope unit="page" to="95">95</biblScope>
</imprint>
<idno type="ISSN">1521-6942</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1521-6942</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Sjögren's syndrome</term>
<term>autoantibodies</term>
<term>autoimmune epithelitis</term>
<term>autoimmune exocrinopathy</term>
<term>autoimmune rheumatic diseases</term>
<term>diagnosis</term>
<term>differential diagnosis</term>
<term>epithelial cells</term>
<term>exocrine glands</term>
<term>lymphoma</term>
<term>primary Sjögren's syndrome</term>
<term>secondary Sjögren's syndrome</term>
<term>severity index</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Aberrant activation</term>
<term>Aberrant expression</term>
<term>American journal</term>
<term>Atrophic gastritis</term>
<term>Autoantibody</term>
<term>Autoimmune</term>
<term>Autoimmune diseases</term>
<term>Autoimmune disorder</term>
<term>Autoimmune epithelitis</term>
<term>Bacterial infection</term>
<term>Biopsy</term>
<term>British journal</term>
<term>Candidate autoantigen</term>
<term>Chronic disease</term>
<term>Chronic reactions</term>
<term>Clinical entities</term>
<term>Clinical features</term>
<term>Clinical pathology</term>
<term>Clinical presentation</term>
<term>Clinical spectrum</term>
<term>Connective tissue disease</term>
<term>Constitutional symptoms</term>
<term>Correct diagnosis</term>
<term>Crest variant</term>
<term>Dental disease</term>
<term>Diagnostic criteria</term>
<term>Diagnostic criterion</term>
<term>Disease activity</term>
<term>Disease complications</term>
<term>Disease course</term>
<term>Disease manifestations</term>
<term>Disease pathogenesis</term>
<term>Disorder</term>
<term>Dryness</term>
<term>Easy fatigue</term>
<term>Elderly individuals</term>
<term>Elderly subjects</term>
<term>Enlargement</term>
<term>Eosin stain</term>
<term>Epithelial</term>
<term>Epithelial apoptosis</term>
<term>Epithelial cells</term>
<term>European community</term>
<term>European criteria</term>
<term>Exocrine</term>
<term>Exocrine glands</term>
<term>Extraglandular</term>
<term>Extraglandular disease</term>
<term>Extraglandular manifestations</term>
<term>Focus score</term>
<term>Follicular bronchiolitis</term>
<term>General population</term>
<term>Gland</term>
<term>Gland biopsy</term>
<term>Gland enlargement</term>
<term>Glandular</term>
<term>Glandular epithelia</term>
<term>Glandular epithelial cells</term>
<term>Glandular tissues</term>
<term>Glomerulonephritis</term>
<term>Higher prevalence</term>
<term>Higher risk</term>
<term>Human virus</term>
<term>Immune</term>
<term>Immune system</term>
<term>Immunological aspects</term>
<term>Immunosuppressive agents</term>
<term>Internal medicine</term>
<term>Interstitial</term>
<term>Interstitial nephritis</term>
<term>Kassan</term>
<term>Lacrimal glands</term>
<term>Lesion</term>
<term>Local application</term>
<term>Lymphocytic</term>
<term>Lymphoma</term>
<term>Lymphoma development</term>
<term>Lymphomatous transformation</term>
<term>Malignant</term>
<term>Malignant lymphoma</term>
<term>Manifestation</term>
<term>Manoussakis</term>
<term>Membranoproliferative glomerulonephritis</term>
<term>Monoclonal</term>
<term>Monoclonal cryoglobulinaemia</term>
<term>Moutsopoulos</term>
<term>Moutsopoulos figure</term>
<term>Mucosal dryness</term>
<term>Nailfold capillaroscopy</term>
<term>Nephritis</term>
<term>Objective tests</term>
<term>Ocular components</term>
<term>Parotid</term>
<term>Parotid glands</term>
<term>Pathogenesis</term>
<term>Peripheral neuropathy</term>
<term>Pilocarpine hydrochloride</term>
<term>Positive response</term>
<term>Positive result</term>
<term>Practical algorithm</term>
<term>Primary biliary cirrhosis</term>
<term>Primary syndrome</term>
<term>Recurrent parotid gland enlargement</term>
<term>Renal</term>
<term>Rheumatic</term>
<term>Rheumatic disease</term>
<term>Rheumatic diseases</term>
<term>Rheumatoid arthritis</term>
<term>Rheumatology</term>
<term>Salivary</term>
<term>Salivary gland enlargement</term>
<term>Salivary gland epithelial cells</term>
<term>Salivary glands</term>
<term>Sarcoidosis</term>
<term>Secondary syndrome</term>
<term>Sequential application</term>
<term>Serological</term>
<term>Serological evaluation</term>
<term>Serum autoantibodies</term>
<term>Serum levels</term>
<term>Sicca</term>
<term>Sicca manifestations</term>
<term>Sicca syndrome</term>
<term>Symptomatic relief</term>
<term>Syndrome</term>
<term>Systemic</term>
<term>Systemic involvement</term>
<term>Systemic lupus erythematosus</term>
<term>Systemic manifestations</term>
<term>Systemic necrotizing vasculitis</term>
<term>Systemic sclerosis</term>
<term>Talal</term>
<term>Unpublished observations</term>
<term>Vaginal dryness</term>
<term>Variable severity</term>
<term>Vasculitis</term>
<term>Xerophthalmia</term>
<term>Xerostomia</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: Sjögren's syndrome (SS) is a chronic autoimmune disorder of the exocrine glands of unknown aetiology, which is typically associated with focal lymphocytic infiltrates of glandular tissues and autoantibody responses against the Ro(SSA) and La(SSB) ribonucleoproteins. In almost one-third of patients disease involves various extraglandular sites, whereas approximately 5% of patients may also develop malignant B-cell lymphoma. In addition, features of SS are frequently encountered (5–20%) in patients with several other autoimmune rheumatic diseases, and in several respects these ‘secondary’ forms may be distinct from SS found alone (primary-SS), as well as from each other. The correct diagnosis and management of SS may require consideration from various specialists. Differential diagnosis includes adverse effects of drugs, sarcoidosis, lipoproteinaemias, age-related atrophy, chronic graft-versus-host disease, lymphomas, amyloidosis and infection by human immunodeficiency virus or hepatitis C virus. Based on the sequential application of the validated European classification criteria for SS, a practical algorithm for diagnosis is presented. Despite progress in the understanding of the broad clinicopathological spectrum of the entity, its treatment remains largely empirical and symptomatic. To date, the decision for systemic therapeutic intervention is primarily based on the severity of extraglandular manifestations.</div>
</front>
</TEI>
<affiliations><list><country><li>Grèce</li>
</country>
<region><li>Attique (région)</li>
</region>
<settlement><li>Athènes</li>
</settlement>
</list>
<tree><country name="Grèce"><region name="Attique (région)"><name sortKey="Manoussakis, Menelaos N" sort="Manoussakis, Menelaos N" uniqKey="Manoussakis M" first="Menelaos N." last="Manoussakis">Menelaos N. Manoussakis</name>
</region>
<name sortKey="Moutsopoulos, Haralampos M" sort="Moutsopoulos, Haralampos M" uniqKey="Moutsopoulos H" first="Haralampos M." last="Moutsopoulos">Haralampos M. Moutsopoulos</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002484 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002484 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:F382C1419359434234091184862183D7082266B1 |texte= Sjögren's syndrome: autoimmune epithelitis }}
This area was generated with Dilib version V0.6.33. |